Can Fioricet Get You High?

NO. I do not think Fioricet can get you high.

One of the key active ingredients responsible for the so-called Fioricet high is butalbital.

butalbital
Butalbital is a barbiturate that’s considered short-to-intermediate acting, and it can relieve symptoms of anxiety, reduce pain, relax muscles and act as a sedative. There are many neuropsychological effects of butalbital, some of which aren’t clearly understood to this day.
The belief is that the Fioricet high is caused by the fact that butalbital can increase the inhibition neurotransmitters in the brain called GABA.
But by rxlist,  the barbiturate butalbital addict per day is usually about 1,500 mg. One pill of fioricet contains 40mg butalbital. if you are taking 1,500mg per day, you will take more than 30 tablet of fioricet which contain 9000mg acetaminophen. If you have taken more than 9000mg acetaminophen, you will die. The max dosage of acetaminophen per day is 3000mg.
Besides,  As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than twofold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller.
The lethal dose of a barbiturate is far less if alcohol is also ingested. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days. Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug.
Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient’s regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.
Fioricet can reduce anxiety and some people with anxiety disorders may take it for this reason, although this is not what it’s approved for. There is the potential for Fioricet to decrease feelings of anxiety even when it’s taken at a normal dose, and this is because of the impact of butalbital on GABA. For some people, a Fioricet high is actually just equated with a reduction in anxiety.
Not everyone will associate the use of this drug with the Fioricet high. Some of the factors that determine whether or not a person will experience a Fioricet high can include the dosage they take and their tolerance. Newer users may be more likely to experience what they would describe as the Fioricet high. Other factors that could influence this include the specific formulation of the drug and whether or not other substances are taken with it. Some people may try to extract the butalbital from Fioricet and remove it from the caffeine and acetaminophen for a greater high.
This is not only drug abuse, but might not even achieve the effects the person is looking for. It’s important to realize that there can be serious and deadly consequences associated with trying to achieve a Fioricet high.
This can include addiction, adverse reactions, brain damage, emotional crashes, and overdose. Since Fioricet has acetaminophen, if people abuse it to get high they may also sustain liver damage or failure.

What is Fioricet side effects ?

Commonly reported side effects for Fioricet include:

  • Euphoria
  • Dizziness
  • Drowsiness
  • Intoxicated feeling
  • Light-headedness
  • Nausea
  • Vomiting
  • Sedation
  • Substance dependence
  • Shortness of breath
  • Abdominal pain

Fioricet is implicated as causing repeat headaches with over-use.

Fioricet Effects of Addiction

Abusing Fioricet or being addicted to it can be incredibly dangerous for multiple reasons. The first is because of the acetaminophen. Acetaminophen in amounts of more than 4000 mg a day can lead to liver damage and acute liver failure, particularly if it’s also combined with alcohol. Then, there’s the dangers of overdose and respiratory depression that can come with the butalbital in Fioricet.
It’s important only to use Fioricet as instructed by your physician to avoid these risks and also to lower your risk of becoming addicted to it. Some of the signs of Fioricet addiction include:
  • Being preoccupied with the use of Fioricet or always trying to find more of it.
  • Doctor shopping to get multiple prescriptions.
  • Taking it any way other than how your doctor instructs you or regularly taking it for recurring headaches.
  • Developing a tolerance to Fioricet is one of the first side effects of Firocet abuse. With tolerance, you have to take higher doses to get an effect. This can not only indicate a Fioricet abuse problem, but it also puts you at a higher risk of an overdose or liver failure.

If you are experiencing Fioricet effects that could indicate you have a problem, it’s important to speak with your doctor. It is possible to develop a tolerance for this drug, as was touched on above, so if you suddenly stop taking it you may experience withdrawal. Your physician or an addiction specialist can help you determine the best actions to take if you have an addiction to barbiturates like Fioricet.

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Fioricet dosing information

Usual Adult Dose of Fioricet for Headache:

Acetaminophen 300 mg, butalbital 50 mg, and caffeine 40 mg:
1 or 2 capsule(s) orally every 4 hours as needed. Maximum daily dose: 6 doses.

Acetaminophen 325 mg, butalbital 50 mg, and caffeine 40 mg:
1 or 2 tablet(s), capsule(s), or tablespoonful(s) orally every 4 hours.
Maximum daily dose: 6 doses

Acetaminophen 500 mg, butalbital 50 mg, and caffeine 40 mg:
1 tablet or capsule orally every 4 hours.
Maximum daily dose: 6 doses

Acetaminophen 750 mg, butalbital 50 mg, and caffeine 40 mg:
1 tablet orally every 4 hours.
Maximum daily dose: 5 tablets

Usual Pediatric Dose of Fioricet for Headache:

12 years and older:
Acetaminophen 300 mg, butalbital 50 mg, and caffeine 40 mg:
1 or 2 capsule(s) orally every 4 hours as needed. Maximum daily dose: 6 doses.

What should I know before I take Fioricet ?

Do not use Fioricet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use Fioricet if you are allergic to acetaminophen, butalbital, or caffeine, if you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

To make sure Fioricet is safe for you, tell your doctor if you have:

  • liver disease, cirrhosis, a history of alcoholism or drug addiction, or if you drink more than 3 alcoholic beverages per day;
  • kidney disease;
  • asthma, sleep apnea, or other breathing disorder;
  • stomach ulcer or bleeding;
  • a history of skin rash caused by any medication;
  • a history of mental illness or suicidal thoughts; or
  • if you use medicine to prevent blood clots.

It is not known whether Fioricet will harm an unborn baby. If you use butalbital while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Pharmacology

Mechanism of Action

Butalbital: Barbiturate; elicits generalized CNS depressant effects; depresses sensory cortex; decreases motor activity

Acetaminophen: Nonopioid, nonsalicylate analgesic; acts on hypothalamus to produce analgesia and antipyresis

Caffeine: Vasoconstrictive properties of cerebral blood vessels may be helpful when treating headaches; improves skeletal muscle contraction and medullary respiratory center sensitivity; stimulates central inspiratory drive

Absorption

Butalbital and caffeine: Well absorbed

Bioavailability: 100% acetaminophen

Distribution

Protein bound: Butalbital (45%); acetaminophen (20-50%)

Metabolism

Butalbital

  • Metabolized in liver by CYP450 enzyme system
  • Induces hepatic enzymes, but to lesser degree than phenobarbital

Acetaminophen

  • Metabolized in liver by microsomal enzyme systems
  • 80-85% conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine
  • 4% metabolized by CYP450 to toxic metabolite (N acetyl-p-benzoquinoneimine, N-acetylimidoquinone [NAPQI]), which is detoxified by conjugation with glutathione; high doses may deplete fixed amount of glutathione in body, causing NAPQI accumulation

Caffeine

  • Metabolized in liver via CYP1A2 to paraxanthine, theobromine, and theophylline

Elimination